-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	35311
标题:	Substd. benzamide derivs. and their use as anticon
作者:	Harling, J.D.; Orlek, B.S.; Thompson, M. (SmithKline Beecham plc)
来源:	EP 0906283; US 6110934; WO 9748683

合成路线图解说明: Quaternization of 5-aminoisoquinoline (I) in acetone afforded isoquinolinium salt (II), which was reduced with NaBH4 to the tetrahydroisoquinoline (III). Alternatively, 5-nitroisoquinoline (IV) was quaternized to give (V) and subsequently reduced with NaBH4 to afford 2-methyl-5-nitro-1,2,3,4-tetrahydroisoquinoline (VI), which was further reduced to amine (III) by catalytic hydrogenation over Pd/C. Amine (III) was finally coupled with acid chloride (VII) in the presence of Et3N to provide the title benzamide).

参考文献No.	479501
标题:	Identification of a series of 1,2,3,4-tetrahydrois
作者:	Harling, J.D.; Thompson, M.
来源:	216th ACS Natl Meet (Aug. 23-27, Boston) 1998,Abst MEDI 099

合成路线图解说明: Quaternization of 5-aminoisoquinoline (I) in acetone afforded isoquinolinium salt (II), which was reduced with NaBH4 to the tetrahydroisoquinoline (III). Alternatively, 5-nitroisoquinoline (IV) was quaternized to give (V) and subsequently reduced with NaBH4 to afford 2-methyl-5-nitro-1,2,3,4-tetrahydroisoquinoline (VI), which was further reduced to amine (III) by catalytic hydrogenation over Pd/C. Amine (III) was finally coupled with acid chloride (VII) in the presence of Et3N to provide the title benzamide).