【药物名称】
化学结构式(Chemical Structure):
参考文献No.480051
标题:Synthesis and structure-activity relationships of substituted biaryl, biaryl ether derivatives as uricosuric agents
作者:Nimura, M.; et al.
来源:216th ACS Natl Meet (Aug. 23-27, Boston) 1998,Abst MEDI 169
合成路线图解说明:

By Ullmann condensation of 4-chlorobenzoic acid (I) with 3-hydroxybenzonitrile (II) by means of Cu or CuI and K2CO3 in DMF at 170 C. The same reaction can also be performed with 4-bromo- or 4-iodobenzoic acids instead of 4-chlorobenzoic acid (I).

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