F-12682-药物合成数据库

【药物名称】F-12682

化学结构式(Chemical Structure):

参考文献No.	37964
标题:	Novel aromatic piperazines derived from substd. cycloazanes, method for preparing same, pharmaceutical compsns., and use thereof as drugs
作者:	Jorand-Lebrun, C.; Pauwels, P.; Chopin, P.; Marien, M.; Halazy, S. (Pierre Fabre M閐icament)
来源:	JP 2000505795; WO 9728141

合成路线图解说明: By condensation of 1-(2-phenylethyl)piperazine (I) with 4-methoxy-3-(4-methyl-1-piperazinyl)aniline (II) and triphosgene by means of triethylamine in dichloromethane.

参考文献No.	479599
标题:	Synthesis and pharmacological studies of a new 5HT1B/1D receptors inverse agonist
作者:	Jorand-Lebrun, C.; et al.
来源:	15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998,Abst P.162

合成路线图解说明: By condensation of 1-(2-phenylethyl)piperazine (I) with 4-methoxy-3-(4-methyl-1-piperazinyl)aniline (II) and triphosgene by means of triethylamine in dichloromethane.