LY-367366-药物合成数据库

【药物名称】LY-367366

化学结构式(Chemical Structure):

参考文献No.	37244
标题:	Pharmaceutical substd. propanoic acid derivs.
作者:	Purdey, J.A.; et al. (Eli Lilly and Company)
来源:	EP 0849263; JP 10194734; US 5965103

合成路线图解说明: The condensation of ethyl 2-(4-cyanobenzoyl)acetate (I) with 9-hydroxythioxanthene (II) in ethanol/acetic acid gives ethyl 2-(4-cyanobenzoyl)-2-(thioxanthen-9-yl)acetate (III), which is decarboxylated in refluxing DMSO/water yielding 4-[2-(thioxanthen-9-yl)acetyl]benzonitrile (IV). The cyclization of (IV) with ammonium carbonate and potasium cyanide affords the hydantoin (V), which is finally fully hydrolyzed with aqueous NaOH at 120 C.

参考文献No.	479625
标题:	alpha-Substituted phenylglycines as group 1 metabotropic glutamate receptor antagonists
作者:	Clark, B.P.; et al.
来源:	15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998,Abst P.183

合成路线图解说明: The condensation of ethyl 2-(4-cyanobenzoyl)acetate (I) with 9-hydroxythioxanthene (II) in ethanol/acetic acid gives ethyl 2-(4-cyanobenzoyl)-2-(thioxanthen-9-yl)acetate (III), which is decarboxylated in refluxing DMSO/water yielding 4-[2-(thioxanthen-9-yl)acetyl]benzonitrile (IV). The cyclization of (IV) with ammonium carbonate and potasium cyanide affords the hydantoin (V), which is finally fully hydrolyzed with aqueous NaOH at 120 C.