FUB-349(free base), VUF-5514-药物合成数据库

【药物名称】FUB-349(free base), VUF-5514

化学结构式(Chemical Structure):

参考文献No.	469678
标题:	General construction pattern of histamine H3-receptor antagonists: Change of a paradigm
作者:	Stark, H.; Ligneau, X.; Arrang, J.-M.; Schwartz, J.-C.; Schunack, W.
来源:	Bioorg Med Chem Lett 1998,8(15),2011

合成路线图解说明: The Wittig condensation of 1-tritylimidazole-4-carbaldehyde (I) with triphenyl(3-phenylpropyl)phosphonium bromide (II) and potassium tert-butoxide in THF gives 4-(4-phenyl-1(Z)-butenyl)-1-trityl-1H-imidazole (III), which is deprotected with 6N HCl in refluxing acetone.

合成路线图解说明: The Wittig condensation of 1-tritylimidazole-4-carbaldehyde (I) with triphenyl(3-phenylpropyl)phosphonium bromide (II) and potassium tert-butoxide in THF gives 4-(4-phenyl-1(Z)-butenyl)-1-trityl-1H-imidazole (III), which is deprotected with 6N HCl in refluxing acetone yielding 4-(4-phenyl-1(Z)-butenyl)-1H-imidazole (IV). Finally, this compound is hydrogenated with H2 over Pd/C in methanol.