TPI-药物合成数据库

【药物名称】TPI

化学结构式(Chemical Structure):

参考文献No.	31193
标题:	Uracil derivs., and antitumor effect potentiator and antitumor agent containing the same
作者:	Yano, S.; Tada, Y.; Kazuno, H.; Sato, T.; Yamashita, J.; Suzuki, N.; Emura, T.; Fukushima, M.; Asao, T. (Taiho Pharmaceutical Co., Ltd.)
来源:	EP 0763529; US 5744475; WO 9630346

合成路线图解说明: The chlorination of 6-(chloromethyl)uracil (I) with sulfuryl chloride in acetic acid gives 5-chloro-6-(chloromethyl)uracil (II), which is then condensed with 2-iminopyrrolidine (III) by means of sodium ethoxide in DMF.

参考文献No.	36245
标题:	Cancerous metastasis inhibitors containing uracil derivs.
作者:	Miyadera, K.; Emura, T.; Wierzba, K.; Yamada, Y. (Taiho Pharmaceutical Co., Ltd.)
来源:	EP 0884051; WO 9813045

合成路线图解说明: The chlorination of 6-(chloromethyl)uracil (I) with sulfuryl chloride in acetic acid gives 5-chloro-6-(chloromethyl)uracil (II), which is then condensed with 2-iminopyrrolidine (III) by means of sodium ethoxide in DMF.