【药物名称】
化学结构式(Chemical Structure):
参考文献No.476353
标题:The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase
作者:Xu, T.; Khanna, H.; Coward, J.K.
来源:Bioorg Med Chem 1998,6(10),1821
合成路线图解说明:

Coupling of N-Boc-benzoylphenylalanine (I) with threoninamide (II) using 1-(dimethylaminopropyl)-3-ethylcarbodiimide-HCl (EDC) and 1-hydroxybenzotriazole (HOBt) in the presence of N-methylmorpholine (NMM) afforded the N-Boc-dipeptide (III), which was deprotected with trifluoroacetic acid in CH2Cl2 to give (IV). Further coupling of (IV) with N-Boc-asparagine (V) using EDC and HOBt, followed by Boc deprotection with trifluoroacetic acid, provided tripeptide (VII). Finally, acylation of (VII) with benzoic anhydride in the presence of triethylamine furnished the target benzamide.

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