【药物名称】
化学结构式(Chemical Structure):
参考文献No.46605
标题:Acylated betulin and dihydrobetulin derivs., preparation thereof and use thereof
作者:Sun, I.-C.; Cosentino, L.M.; Lee, K.-H.; Wang, H.-K. (BBI Biotech Research Laboratories, Inc.; University of North Carolina)
来源:US 6172110
合成路线图解说明:

The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.

参考文献No.478949
标题:Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents
作者:Sun, I.-C.; Wang, H.-K.; Kashiwada, Y.; Shen, J.-K.; Cosentino, L.M.; Chen, C.-H.; Yang, L.-M.; Lee, K.-H.
来源:J Med Chem 1998,41(23),4648
合成路线图解说明:

The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.

参考文献No.478950
标题:Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives
作者:Sun, I.C.; Shen, J.K.; Wang, H.K.; Cosentino, L.M.; Lee, K.H.
来源:Bioorg Med Chem Lett 1998,8(10),1267-1272
合成路线图解说明:

The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.

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