-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	478960
标题:	Synthesis, activity, and molecular modeling of new 2,4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors
作者:	Fresneau, P.; Cussac, M.; Morand, J.M.; Szymonski, B.; Tranqui, D.; Leclerc, G.
来源:	J Med Chem 1998,41(24),4706

合成路线图解说明: 1-Methoxynaphthalene (I) was lithiated with n-butyllithium and subsequently treated with N-methylformanilide (II) to give the 2-naphthaldehyde (III). The Knoevenagel condensation of (III) with the rhodanineacetic acid (IV) in the presence of NaOAc in AcOH provided the target 5-(alkylidene)thiazolidine.