SMP-114-药物合成数据库

【药物名称】SMP-114

化学结构式(Chemical Structure):

参考文献No.	37653
标题:	Isoxazole derivs.
作者:	Ueno, Y.; Okada, S.; Nakatsuka, M.; Nishikaku, F. (Sumitomo Pharmaceuticals Co., Ltd.)
来源:	EP 0979226; JP 1999240873; US 6100260; WO 9847880

合成路线图解说明: The condensation of 2(S)-(2-fluorobiphenyl-4-yl)propionic acid (I) with tert-butyl cyanacetate (II) by means of lithium amide in THF gives lithium enolate (III), which is cyclized with hydroxylamine in aqueous DMF to yield the 5-aminoisoxazole (IV). Finally, this compound is condensed with morpholine-4-carbonitrile by means of lithium amide in toluene/tert-butanol to afford the target amidine.

参考文献No.	629840
标题:	Novel disease modifying anti-rheumatic agents (DMARDs): Syntheses and SAR of 5-guanidinoisoxazoles
作者:	Nakatsuka, M.; et al.
来源:	222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001,Abst MEDI 269

合成路线图解说明: The condensation of 2(S)-(2-fluorobiphenyl-4-yl)propionic acid (I) with tert-butyl cyanacetate (II) by means of lithium amide in THF gives lithium enolate (III), which is cyclized with hydroxylamine in aqueous DMF to yield the 5-aminoisoxazole (IV). Finally, this compound is condensed with morpholine-4-carbonitrile by means of lithium amide in toluene/tert-butanol to afford the target amidine.