【药物名称】
化学结构式(Chemical Structure):
参考文献No.37665
标题:Heterocyclic cpds. and their preparation and use
作者:Sauerberg, P.; Jeppesen, L. (Novo Nordisk A/S)
来源:EP 0977755; US 6015813; WO 9847900
合成路线图解说明:

Treatment of endo-(+)-3-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane (I) with sodium hydrosulfide in hot DMF afforded the intermediate thiol (II), which was further condensed with 3-phenyl-2-propyn-1-yl mesylate (III) to yield the corresponding thioether. This compound was finally isolated as the tartrate salt.

参考文献No.477035
标题:Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation
作者:Sauerberg, P.; Jeppesen, L.; Olesen, P.H.; Sheardown, M.J.; Fink-Jensen, A.; Rasmussen, T.; Rimvall, K.; Shannon, H.E.; Bymaster, F.P.; DeLapp, N.W.; Calligaro, D.O.; Ward, J.S.; Whitesitt, C.A.; Thomsen, C.
来源:Bioorg Med Chem Lett 1998,8(20),2897
合成路线图解说明:

Treatment of endo-(+)-3-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane (I) with sodium hydrosulfide in hot DMF afforded the intermediate thiol (II), which was further condensed with 3-phenyl-2-propyn-1-yl mesylate (III) to yield the corresponding thioether. This compound was finally isolated as the tartrate salt.

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