-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	37665
标题:	Heterocyclic cpds. and their preparation and use
作者:	Sauerberg, P.; Jeppesen, L. (Novo Nordisk A/S)
来源:	EP 0977755; US 6015813; WO 9847900

合成路线图解说明: Treatment of endo-(+)-3-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane (I) with sodium hydrosulfide in hot DMF afforded the intermediate thiol (II), which was further condensed with 3-phenyl-2-propyn-1-yl mesylate (III) to yield the corresponding thioether. This compound was finally isolated as the tartrate salt.

参考文献No.	477035
标题:	Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation
作者:	Sauerberg, P.; Jeppesen, L.; Olesen, P.H.; Sheardown, M.J.; Fink-Jensen, A.; Rasmussen, T.; Rimvall, K.; Shannon, H.E.; Bymaster, F.P.; DeLapp, N.W.; Calligaro, D.O.; Ward, J.S.; Whitesitt, C.A.; Thomsen, C.
来源:	Bioorg Med Chem Lett 1998,8(20),2897

合成路线图解说明: Treatment of endo-(+)-3-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane (I) with sodium hydrosulfide in hot DMF afforded the intermediate thiol (II), which was further condensed with 3-phenyl-2-propyn-1-yl mesylate (III) to yield the corresponding thioether. This compound was finally isolated as the tartrate salt.