-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	483532
标题:	Synthesis of 6(alpha,beta)-aminocholestanols as ergosterol biosynthesis inhibitors
作者:	Beuchet, P.; el Kihel, L.; Dherbomez, M.; Charles, G.; Letourneux, Y.
来源:	Bioorg Med Chem Lett 1998,8(24),3627

合成路线图解说明: Nitration of cholesteryl acetate (I) with nitric acid in acetic acid gave the 6-nitro derivative (II). Reduction of the D5 double bond of (II) with ethanolic NaBH4 at reflux temperature provided the 6-alpha-nitro compound (III). Finally, reduction of the nitro group of (III) with concomitant deacetylation using hydrazine and Pd/C in EtOH yielded the title compound.

合成路线图解说明: Nitration of cholesteryl acetate (I) with nitric acid in acetic acid gave the 6-nitro derivative (II). Reduction of the D5 double bond of (II) with ethanolic NaBH4 at room temperature provided the 6-beta-nitro compound (III). Finally, reduction of the nitro group of (III) with concomitant deacetylation using LiAlH4 in refluxing Et2O yielded the title compound.