【药物名称】
化学结构式(Chemical Structure):
参考文献No.486227
标题:Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: Investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1H-phenothiazin-4[10H]-one derivatives
作者:Laws, M.L.; Roberts, R.R.; Nicholson, J.M.; Butcher, R.; Stables, J.P.; Goodwin, A.M.; Smith, C.A.; Scott, K.R.
来源:Bioorg Med Chem 1998,6(12),2289
合成路线图解说明:

The reaction of 4-bromoaniline (I) with potassium thiocyanate and bromine in acetic acid gives the benzothiazole (III) through the intermediate (II). The hydrolysis of (III) with NaOH affords 4-bromo-2-sulfanylaniline (IV), which is cyclized with 4-hydroxy-6-methyl-2-oxo-3-cyclohexene-1-carboxylic acid tert-butyl ester (V) in refluxing toluene.

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