ACEA-药物合成数据库

【药物名称】ACEA

化学结构式(Chemical Structure):

参考文献No.	483852
标题:	Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
作者:	Lin, S.; Khanolkar, A.D.; Fan, P.; Goutopoulos, A.; Qin, C.; Papahadjis, D.; Makriyannis, A.
来源:	J Med Chem 1998,41(27),5353

合成路线图解说明: Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C, followed by condensation with propargylamine (III).

合成路线图解说明: Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C, followed by condensation with 2-chloroethylamine - HCl (III) in the presence of pyridine.

参考文献No.	539998
标题:	Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)
作者:	Hillard, C.J.; Manna, S.; Greenberg, M.J.; Dicamelli, R.; Ross, R.A.; Stevenson, L.A.; Murphy, V.; Pertwee, R.G.; Campbell, W.B.
来源:	J Pharmacol Exp Ther 1999,289(3),1427

合成路线图解说明: Arachidonic acid (I) was converted to the mixed anhydride (II) upon treatment with isobutyl chloroformate and triethylamine. Subsequent condensation of (II) with 2-chloroethylamine (III) provided the target amide.

合成路线图解说明: Arachidonic acid (I) was converted to the mixed anhydride (II) upon treatment with isobutyl chloroformate and triethylamine. Subsequent condensation of (II) with cyclopropylamine (III) provided the target amide.