Methanandamide-(R), (R)-Methanandamide-药物合成数据库

【药物名称】Methanandamide-(R), (R)-Methanandamide

化学结构式(Chemical Structure):

参考文献No.	297079
标题:	(R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability
作者:	Abadji, V.; Lin, S.; Taha, G.; Griffin, G.; Stevenson, L.A.; Pertwee, R.G.; Makriyannis, A.
来源:	J Med Chem 1994,37(12),1889

合成路线图解说明: Treatment of arachidonic acid (I) with oxalyl chloride in benzene containing DMF afforded acid chloride (II), which was then coupled to (R)-2-amino-1-propanol (III) in THF to yield the corresponding arachidonic acid amide.