【药物名称】
化学结构式(Chemical Structure):
参考文献No.485778
标题:Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity
作者:Hirata, K.; Ito, C.; Furukawa, H.; Itoigawa, M.; Cosentino, L.M.; Lee, K.H.
来源:Bioorg Med Chem Lett 1999,9(2),119
合成路线图解说明:

The reaction of 2-methoxy-9-methylcarbazole-3-carbaldehyde (I) with malonic acid gives the propenoic acid (III), which by treatment with sodium azide and ethyl chloroformate is converted into the azide (IV). The cyclization of (IV) in refluxing ortho-dichlorobenzene affords 5-methoxy-7-methyl-2,7-dihydro-1H-pyrido [4,3-c]carbazol-1-one (V), which by treatment with POCl3 is converted into the 1-chloro derivative (VI). Finally, this compound is dechlorinated by hydrogenation with H2 over Pd/C.

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