-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	42458
标题:	Thiazoline acid derivs.
作者:	Bergeron, R.J. Jr. (University of Florida)
来源:	WO 0012493

合成路线图解说明: Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH. Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.

参考文献No.	486205
标题:	Desazadesmethyldesferrithiocin analogues as orally effective iron chelators
作者:	Bergeron, R.J.; Wiegand, J.; Weimar, W.R.; Vinson, J.R.; Bussenius, J.; Yao, G.W.; McManis, J.S.
来源:	J Med Chem 1999,42(1),95

合成路线图解说明: Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH. Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.