SO-730-药物合成数据库

【药物名称】SO-730

化学结构式(Chemical Structure):

参考文献No.	376828
标题:	Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
作者:	Balzarini, J.; De Clercq, E.; Sheeka, H.M.; Cahard, D.; McGuigan, C.
来源:	Bioorg Med Chem Lett 1996,6(10),1183

合成路线图解说明: Title phosphoramidate was obtained by condensation of phenyl (benzyloxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

参考文献No.	481009
标题:	Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T)
作者:	McGuigan, C.; Sutton, P.W.; Cahard, D.; Turner, K.; O'Leary, G.; Wang, Y.; Gumbleton, M.; De Clercq, E.; Balzarini, J.
来源:	Antivir Chem Chemother 1998,9(6),473

合成路线图解说明: Title phosphoramidate was obtained by condensation of phenyl [(2-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

合成路线图解说明: Title phosphoramidate was obtained by condensation of phenyl (phenoxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

合成路线图解说明: Title phosphoramidate was obtained by condensation of phenyl (benzyloxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

合成路线图解说明: Title phosphoramidate was obtained by condensation of phenyl [(1-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.