Thymectacin, NB-1011, NB-101-药物合成数据库

【药物名称】Thymectacin, NB-1011, NB-101

化学结构式(Chemical Structure):

参考文献No.	50597
标题:	Enzyme catalyzed therapeutic agents
作者:	Shepard, H.M. (NewBiotics, Inc.)
来源:	EP 1167972; JP 2001220397; US 6245750; WO 9937753

合成路线图解说明: The title compound was synthesized by coupling 5-(bromovinyl)-2'-deoxyuridine (I) with phenyl L-methoxyalanino phosphoroamidate (II) in the presence of imidazole in DMF.

参考文献No.	707375
标题:	An improved procedure for the synthesis of nucleoside phosphoramidates
作者:	Vaino, A.R.; Lobl, T.J.; Baehr, D.N.; Lehsten, D.M.
来源:	Org Process Res Dev 2002,6(6),819

合成路线图解说明: The title compound was synthesized by coupling 5-(bromovinyl)-2'-deoxyuridine (I) with phenyl L-methoxyalanino phosphoroamidate (II) in the presence of imidazole in DMF.