【药物名称】DO-897, BP-4.897, BP-897
化学结构式(Chemical Structure):
参考文献No.38414
标题:2-Naphthamide derivs. and their therapeutic applications
作者:Mann, A.; Sokoloff, P.; Schwartz, J.-C.; Wermuth, C.-G.; Garrido, F.; Lecomte, J.-M. (INSERM (Institut National de la Sante et de la Recherche Medicale); Societe Civile Bioprojet)
来源:EP 0779284; FR 2742149; US 5872119; US 5985895
合成路线图解说明:

N-(2-Methoxyphenyl)piperazine (I) was alkylated with 4-bromobutyronitrile (II) to provide the 3-cyanopropylpiperazine (III). Subsequent reduction of the cyano group of (III) using LiAlH4 produced the primary amine (IV). The title amide was then obtained by condensation of (IV) with 2-naphthoic acid (V) after activation as the corresponding acid chloride with (COCl)2 or as the mixed anhydride with isobutyl chloroformate.

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