【药物名称】EGIS-9637
化学结构式(Chemical Structure):
参考文献No.38502
标题:1,3-Dioxolo[4,5-h][2,3]benzodiazepine derivs. as AMPA/kainate receptor inhibitors
作者:Simig, G.; Sim? A.; Gacs醠yi, I.; Gigler, G.; Szab? G.; Seres, P.; Gyerty醤, I.; Egyed, A.; Szabados, T.; K髏ay Nagy, P.; Kov醕s, A.; Bal醶s, L.; Greff, Z.; L関ay, G.; R醫kai, Z.; V間h, M.; et al. (Egis Pharmaceuticals Ltd.)
来源:EP 1015457; WO 9907708
合成路线图解说明:

The known 7,8-dihydro-8-methyl-5-(4-nitrophenyl)-9H-1,3-dioxolo-[4,5-h]-2,3-benzodiazepine (I) was condensed with 1,1'-carbonyldiimidazole (II) in refluxing THF to produce imidazolide (III). Subsequent reaction of (III) with boiling cyclopropylamine (IV) gave rise to the cyclopropylcarbamoyl derivative (V). The nitro group of (V) was then reduced to the corresponding amine by hydrogenation over Pd/C.

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