CO-122739-药物合成数据库

【药物名称】CO-122739

化学结构式(Chemical Structure):

参考文献No.	27743
标题:	Androstanes and pregnanes for allosteric modulation of GABA receptor
作者:	Upasani, R.B.; Xia, H.; Hogenkamp, D. (CoCensys, Inc.)
来源:	EP 0752860; EP 1038880; JP 1997510701; WO 9521617

合成路线图解说明: The bromination of 3-alpha-hydroxy-3-beta-methyl-5-alpha-pregnan-20-one (I) with Br2 in acidic methanol gives the 21-bromo derivative (II), which is then treated with sodium thiosulfate in ethanol/water.

参考文献No.	529972
标题:	Sodium S-(3alpha-hydroxypregnan-20-on-21-yl)thiosulfates: Allosteric modulators of the GABAA receptor
作者:	Acosta-Burruel, M.; Hawkinson, J.E.; Fick, D.B.; et al.
来源:	217th ACS Natl Meet (March 21 1999, Anaheim) 1999,Abst MEDI 098

合成路线图解说明: The bromination of 3-alpha-hydroxy-3-beta-methyl-5-alpha-pregnan-20-one (I) with Br2 in acidic methanol gives the 21-bromo derivative (II), which is then treated with sodium thiosulfate in ethanol/water.