13-Deoxydoxorubicin hydrochloride, 13-deoxyadriamycin hydrochloride, GPX-100-药物合成数据库

【药物名称】13-Deoxydoxorubicin hydrochloride, 13-deoxyadriamycin hydrochloride, GPX-100

化学结构式(Chemical Structure):

参考文献No.	38560
标题:	13-Deoxyanthracycline derivs. and processes for preparing them
作者:	Olson, R.D.; Zhang, X.; Walsh, G.M. (Gem Pharmaceuticals, Inc.)
来源:	EP 1011687; JP 2001515040; WO 9908687

合成路线图解说明: Adriamycin hydrochloride (I) was converted to the tosylhydrazone (II) upon treatment with p-toluenesulfonylhydrazide in methanol. Subsequent reduction of the hydrazone functionality of (II) by means of sodium cyanoborohydride in the presence of p-toluenesulfonic acid furnished the title deoxygenated Adriamycin.

参考文献No.	639179
标题:	Adriamycin analogues. 2. Synthesis of 13-deoxyanthracyclines
作者:	Smith, T.H.; Fujiwara, A.N.; Henry, D.W.
来源:	J Med Chem 1978,21(3),280

合成路线图解说明: Adriamycin hydrochloride (I) was converted to the tosylhydrazone (II) upon treatment with p-toluenesulfonylhydrazide in methanol. Subsequent reduction of the hydrazone functionality of (II) by means of sodium cyanoborohydride in the presence of p-toluenesulfonic acid furnished the title deoxygenated Adriamycin.