-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	39007
标题:	Drug therapy
作者:	Khan, T. (Aepact Ltd.)
来源:	WO 9720580

合成路线图解说明: The reaction of L-glutamic acid di tert-butyl ester (I) with 4-nitrophenyl chloroformate (II) by means of triethylamine in dichloromethane gives the corresponding carbamate (III), which is treated with 4-methoxythiophenol (IV) in dichloromethane to afford the thiocarbamate (V). Finally, this compound is treated with HCl.

参考文献No.	529514
标题:	Novel inhibitors of carboxypeptidase G2 (CPG2): Potential use in antibody-directed enzyme prodrug therapy
作者:	Khan, T.H.; Eno-Amooquaye, E.A.; Searle, F.; Browne, P.J.; Osborn, H.M.; Burke, P.J.
来源:	J Med Chem 1999,42(6),951

合成路线图解说明: The reaction of L-glutamic acid di tert-butyl ester (I) with 4-nitrophenyl chloroformate (II) by means of triethylamine in dichloromethane gives the corresponding carbamate (III), which is treated with 4-methoxythiophenol (IV) in dichloromethane to afford the thiocarbamate (V). Finally, this compound is treated with HCl.