91-454-药物合成数据库

【药物名称】91-454

化学结构式(Chemical Structure):

参考文献No.	524583
标题:	Synthesis and antileishmanial activity of alpha-cyano ethyl propenoates - A new class of antileishmanials
作者:	Tiwari, S.; et al.
来源:	Arzneim-Forsch Drug Res 1999,49(2),144

合成路线图解说明: By condensation of 3-methoxybenzaldehyde (I) with ethyl cyanoacetate (II) by means of NaOH in ethanol.

合成路线图解说明: The condensation of 4-hydroxy-3-methoxybenzaldehyde (I) with ethyl cyanoacetate (II) by means of NaOH in ethanol gives the 2-cyanopropenoate (III), which is then alkylated at the OH group with ethyl 2-bromoacetate (IV) by means of K2CO3 and tetrabutylammonium bromide in THF.