MPB-27-药物合成数据库

【药物名称】MPB-27

化学结构式(Chemical Structure):

参考文献No.	35865
标题:	CFTR channel activator cpds. and pharmaceutical compsns. containing same
作者:	Becq, F.; Mettey, Y.; Vierfond, J.-M.; Verrier, B.; Gola, M. (CNRS (Centre National de la Recherche Scientifique))
来源:	EP 0937044; WO 9805642

合成路线图解说明: The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

合成路线图解说明: The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

参考文献No.	413992
标题:	Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II
作者:	Mettey, Y.; Vierfond, J.-M.
来源:	Bioorg Med Chem Lett 1997,7(8),961

合成路线图解说明: The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

合成路线图解说明: The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.