SCRC-2941-18-药物合成数据库

【药物名称】SCRC-2941-18

化学结构式(Chemical Structure):

参考文献No.	531836
标题:	4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice
作者:	Yamaguchi, K.; Yada, M.; Tsuji, T.; Hatanaka, Y.; Goda, K.; Kobori, T.
来源:	Bioorg Med Chem Lett 1999,9(7),957

合成路线图解说明: Bromination of 4'-chloropropiophenone (I) afforded bromoketone (II). This was cyclized with thiourea (III) to produce the target 4-arylthiazole.