-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	534883
标题:	Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase
作者:	Arcadi, A.; Asti, C.; Brandolini, L.; Caselli, G.; Marinelli, F.; Ruggieri, V.
来源:	Bioorg Med Chem Lett 1999,9(9),1291

合成路线图解说明: Condensation of of 2-iodoaniline (I) with vinyl triflate (II) in the presence of Pd(PPh3)4 and K2CO3 under atmosphere of CO produced the intermediate amide, which underwent an annellation reaction to the title benzoxazinone.