【药物名称】
化学结构式(Chemical Structure):
参考文献No.534886
标题:Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis
作者:Barn, D.R.; Bom, A.; Cottney, J.; Caulfield, W.L.; Morphy, J.R.
来源:Bioorg Med Chem Lett 1999,9(9),1329
合成路线图解说明:

4-Benzoylbenzoic acid (I) was reduced with NaBH4 in EtOH, and the resulting alcohol (II) was treated with PBr3 to yield bromoacid (III). This was then coupled to Wang resin using diisopropylcarbodiimide and DMAP. The Wang resin-bound bromoester (IV) was condensed with diamine (V) to produce (VI). Finally, aminolysis of the resin bound aminoester (VI) was carried out by means of Et2NH in the presence of AlCl3 to yield the title diethylamide.

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