SB-268091-药物合成数据库

【药物名称】SB-268091

化学结构式(Chemical Structure):

参考文献No.	39237
标题:	Pleuromutilin derivs. as antimicrobials
作者:	Dabbs, S.; Hunt, E.; Berry, V.; Woodnutt, G.; Sanderson, F.D.; Frydrych, C.H. (SmithKline Beecham Corp.; SmithKline Beecham plc)
来源:	EP 1028961; WO 9921855

合成路线图解说明: Treatment of pleuromutilin (I) with p-toluenesulfonyl chloride in pyridine at low temperature provided mutilin 14-(p-toluenesulfonyloxy)acetate (II). Subsequent condensation with quinuclidin-4-thiol hydrobromide (III) in the presence of NaOEt yielded the title sulfide.

合成路线图解说明: By condensation of mesylate (IV) with quinuclidin-4-thiol hydrochloride (V) in the presence of NaOMe.

参考文献No.	701147
标题:
作者:	Zhu, C.F.; et al.
来源:	J Antibiot 1976,29(2),132

合成路线图解说明: Treatment of pleuromutilin (I) with p-toluenesulfonyl chloride in pyridine at low temperature provided mutilin 14-(p-toluenesulfonyloxy)acetate (II). Subsequent condensation with quinuclidin-4-thiol hydrobromide (III) in the presence of NaOEt yielded the title sulfide.