【药物名称】
化学结构式(Chemical Structure):
参考文献No.537115
标题:delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole
作者:Coop, A.; Rothman, R.B.; Dersch, C.; Partilla, J.; Porreca, F.; Davis, P.; Jacobson, A.E.; Rice, K.C.
来源:J Med Chem 1999,42(9),1673
合成路线图解说明:

N-Cyclopropylmethylnorcodeine (I) was converted to thebainone (II) upon treatment with butyllithium, and then hydrogenated over Pd/C to afford dihydrothebainone (III). Then, Fischer indole synthesis of (III) with phenylhydrazine in the presence of p-toluenesulfonic acid furnished the title compound.

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