-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	538851
标题:	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives
作者:	Moreau, P.; Anizon, F.; Sancelme, M.; Prudhomme, M.; Severe, D.; Riou, J.F.; Goossens, J.F.; Henichart, J.P.; Bailly, C.; Labourier, E.; Tazzi, J.; Fabbro, D.; Meyer, T.; Aubertin, A.M.
来源:	J Med Chem 1999,42(10),1816

合成路线图解说明: The dechlorinated rebeccamycin anhydride (II) was prepared from rebeccamycin (I) by hydrogenolysis using Raney Nickel in aqueous sodium hydroxide. Further bromination of (II) with N-bromosuccinimide afforded dibromo derivative (III). Imide (IV) was then prepared by treatment of anhydride (III) with ammonium acetate at 180 C.

参考文献No.	607158
标题:	Syntheses and biological evaluation of indolocarbazoles, analogues of Rebeccamycin, modified at the imide heterocyclic
作者:	Moreau, P.; Anizon, F.; Sancelme, M.; Prudhomme, M.; Bailly, C.; Carrasco, C.; Ollier, M.; Severe, D.; Riou, J.F.; Fabbro, D.; Meyer, T.; Aubertin, A.M.
来源:	J Med Chem 1998,41(10),1631

合成路线图解说明: The dechlorinated rebeccamycin anhydride (II) was prepared from rebeccamycin (I) by hydrogenolysis using Raney Nickel in aqueous sodium hydroxide. Further bromination of (II) with N-bromosuccinimide afforded dibromo derivative (III). Imide (IV) was then prepared by treatment of anhydride (III) with ammonium acetate at 180 C.