【药物名称】(?-PPG
化学结构式(Chemical Structure):
参考文献No.97785
标题:Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists
作者:Bigge, C.F.; et al.
来源:J Med Chem 1989,32(7),1580-90
合成路线图解说明:

Condensation of alpha-hydroxyhippuric acid (II) with bromobenzene (I) in methanesulfonic acid afforded the phenylglycine derivative (III). Further incorporation of the phosphonic acid was effected by palladium-catalyzed displacement of the bromide by diethyl phosphite to give (IV). Finally, acid hydrolysis of the benzamide and phosphite ester groups furnished the title compound.

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