【药物名称】
化学结构式(Chemical Structure):
参考文献No.539889
标题:Synthesis and benzodiazepine receptor (omega receptor) affinities of 3-substituted derivatives of pyrrolo[2,3-c]pyridine-5-carboxylate, a novel class of omega1 selective ligands
作者:Doisy, X.; Dekhane, M.; Le Hyaric, M.; Rousseau, J.F.; Singh, S.K.; Tan, S.; Guilleminot, V.; Schoemaker, H.; Sevrin, M.; George, P.; Potier, P.; Dodd, R.H.
来源:Bioorg Med Chem 1999,7(5),921
合成路线图解说明:

Ethyl 6-azaindole-3-carboxylate (I) was formylated using dichloromethyl methyl ether and AlCl3 to provide aldehyde (II). Nitrogen protection in (II) with benzenesulfonyl chloride and NaH gave sulfonyl derivative (III). Subsequent Wittig condensation of (III) with (ethoxycarbonylmethylene)triphenyl phosphorane produced the unsaturated ester (IV). Finally, removal of the benzenesulfonyl protecting group of (IV) was effected by treatment with ethanolic NaOEt.

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