【药物名称】Irampanel hydrochloride, BIIR-561-CL
化学结构式(Chemical Structure):
参考文献No.36421
标题:Oxadiazoles, processes for their preparation and their use as medicaments
作者:Brenner, M.; Maier, R.; Wienrich, M.; Weiser, T.; Palluk, R.; Bechtel, W.-D.; Sagrada, A.; Ensinger, H.; Pschorn, U.; Cesana, R. (Boehringer Ingelheim GmbH)
来源:DE 19643037; EP 0934288; JP 2000505089; WO 9817652
合成路线图解说明:

The condensation between benzamidoxime (I) and methyl salicylate (II) in the presence of NaOEt under microwave irradiation generated oxadiazole (III). Subsequent alkylation of the hydroxyl group of (III) with dimethylaminoethyl chloride and NaH in dioxan produced the target aminoethyl ether, which was finally isolated as the corresponding hydrochloride salt.

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