The condensation of ethyl indole-2-carboxylate (I) with dodecanoic acid (II) in the presence of polyphosphoric acid and trifluoroacetic anhydride produced the corresponding 3-dodecanoylindole (III). Subsequent alkylation of (III) with ethyl 4-(2-bromoethoxy)phenylacetate (IV) using potassium tert-butoxide in DMSO afforded the N-alkylated indole (V). The ethyl ester groups of (V) were finally hydrolyzed with KOH to provide the target diacid compound.