9-Nitropaullone, Alsterpaullone, NSC-705701-药物合成数据库

【药物名称】9-Nitropaullone, Alsterpaullone, NSC-705701

化学结构式(Chemical Structure):

参考文献No.	545744
标题:	Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity
作者:	Schultz, C.; Link, A.; Leost, M.; Zaharevitz, D.W.; Gussio, R.; Sausville, E.A.; Meijer, L.; Kunick, C.
来源:	J Med Chem 1999,42(15),2909

合成路线图解说明: The condensation of p-nitrophenylhydrazine (I) with benzazepinedione (II) in AcOH produced hydrazone (III). Subsequent Fischer indole synthesis employing (III) and H2SO4 furnished the title indolobenzazepinone.