【药物名称】
化学结构式(Chemical Structure):
参考文献No.541740
标题:Self-immolative anthracycline prodrugs for suicide gene therapy
作者:Niculescu-Duvaz, I.; Niculescu-Duvaz, D.; Friedlos, F.; Spooner, R.; Martin, J.; Marais, R.; Springer, C.J.
来源:J Med Chem 1999,42(13),2485
合成路线图解说明:

Coupling of 4-aminobenzyl alcohol (I) with diallyl L-glutamylisocyanate (II) produced the urea derivative (III). Subsequent activation of the benzylic alcohol group with 4-nitrophenyl chloroformate (IV) afforded carbonate (V). This was then condensed with doxorubicin (VI) to furnish the corresponding carbamate (VII). Finally, palladium-catalyzed cleavage of the allyl esters of (VII) yielded the title compound.

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