-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	542742
标题:	Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides
作者:	Strekowski, L.; Zegrocka, O.; Henary, M.; Say, M.; Mokrosz, M.J.; Kotecka, B.M.; Manzel, L.; Macfarlane, D.E.
来源:	Bioorg Med Chem Lett 1999,9(13),1819

合成路线图解说明: The condensation of 4-chloro-2-(2-naphthyl)quinoline (I) with p-aminophenol (II) at 130 C provided the corresponding 4-anilinoquinoline (III). Then, Mannich reaction of (III) with N-methylpiperazine (IV) and formaldehyde furnished the title compound.