N-(2,3-Epoxypropyl)piperidine (III), prepared from piperidine (I) and epichlorhydrin (II), was condensed with nicotinic acid amidoxime (IV) in the presence of basic catalysts, such as NaOH, t-BuOK, Al2O3 or SnO2, in hot DMF to provide the title compound, which was finally converted to the dihydrochloride salt.

Alternatively, the title compound was prepared by condensation of nicotinamidoxime (IV) with 1,1-pentamethylene-3-hdroxyazetidinium chloride (V).

In a further procedure, nicotinamidoxime (IV) was condensed with 1-chloro-3-piperidino-2-propanol (VI) in the presence of ethanolic NaOEt.