【药物名称】
化学结构式(Chemical Structure):
参考文献No.458741
标题:Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles
作者:Unverferth, K.; Engel, J.; Hofgen, N.; Rostock, A.; Gunther, R.; Lankau, H.J.; Menzer, M.; Rolfs, A.; Liebscher, J.; Muller, B.; Hofmann, H.J.
来源:J Med Chem 1998,41(1),63
合成路线图解说明:

(4-Chlorophenyl)thioacetic acid morpholide (II) was prepared by Willgerodt-Kindler reaction of 4'-chloroacetophenone (I) with sulfur and morpholine. Subsequent condensation of (II) with triethyl orthoformate and morpholine provided the 3-(4-morpholinyl)thioacrylic acid morpholide (IIIa-b). Finally, ring closure of (IIIa-b) with hydrazine hydrochloride in refluxing EtOH furnished the title pyrazole.

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