C-1330-7, CT-50547-药物合成数据库

【药物名称】C-1330-7, CT-50547

化学结构式(Chemical Structure):

参考文献No.	40037
标题:	Platelet ADP receptor inhibitors
作者:	Jantzen, H.-M.; Scarborough, R.M.; Conley, P.B.; Fretto, L.J.; Laibelman, A.M. (COR Therapeutics, Inc.)
来源:	EP 1047699; JP 2002509152; WO 9936425

合成路线图解说明: The title compound was obtained in a one-step procedure from 6-ethoxy-2-aminobenzothiazole (I) and chlorosulfonylacetyl chloride (II) in the presence of triethylamine. The initially formed sulfonamido acid chloride (III) cyclized to the benzothiazolo[2,3-c]thiadiazine ring system (IV), which subsequently underwent further acylation with another molecule of acid chloride (III) to furnish the title compound.

参考文献No.	631313
标题:	Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y12)
作者:	Scarborough, R.M.; Laibelman, A.M.; Clizbe, L.A.; Fretto, L.J.; Conley, P.B.; Reynolds, E.E.; Sedlock, D.M.; Jantzen, H.
来源:	Bioorg Med Chem Lett 2001,11(14),1805

合成路线图解说明: The title compound was obtained in a one-step procedure from 6-ethoxy-2-aminobenzothiazole (I) and chlorosulfonylacetyl chloride (II) in the presence of triethylamine. The initially formed sulfonamido acid chloride (III) cyclized to the benzothiazolo[2,3-c]thiadiazine ring system (IV), which subsequently underwent further acylation with another molecule of acid chloride (III) to furnish the title compound.