SC-299-药物合成数据库

【药物名称】SC-299

化学结构式(Chemical Structure):

参考文献No.	31702
标题:	Substd. oxazoles for the treatment of inflammation
作者:	Talley, J.J.; Bertenshaw, S.; Rogier, D.J. Jr.; Graneto, M.; Brown, D.L.; Devadas, B.; Hwang-Fun, L.; Sikorski, J.A. (Pharmacia Corp.)
来源:	EP 0825989; JP 1999509835; WO 9636617

合成路线图解说明: Chlorosulfonation of the commercially available 2-methyl-4,5-diphenyloxazole (I) with ClSO3H afforded sulfonyl chloride (II), which was then reacted with ammonium hydroxide to produce the title sulfonamide.

参考文献No.	539229
标题:	4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)
作者:	Talley, J.J.; Bertenshaw, S.R.; Brown, D.L.; Carter, J.S.; Graneto, M.J.; Koboldt, C.M.; Masferrer, J.L.; Norman, B.H.; Rogier, D.J. Jr.; Zwwifel, B.S.; Seibert, K.
来源:	Med Res Rev 1999,9(3),199

合成路线图解说明: Chlorosulfonation of the commercially available 2-methyl-4,5-diphenyloxazole (I) with ClSO3H afforded sulfonyl chloride (II), which was then reacted with ammonium hydroxide to produce the title sulfonamide.