【药物名称】Tomeglovir, BAY-38-4766
化学结构式(Chemical Structure):
参考文献No.40120
标题:Novel naphthyl-substd. and anilide-substd. sulfonamides
作者:Trappe, J.; Weber, O.; Eckenberg, P.; Hallenberger, S.; Bender, W.; Goldmann, S.; H鋜ter, M.; Reefschl鋑er, J. (Bayer AG)
来源:WO 9937609
合成路线图解说明:

The reaction of 5-(dimethylamino)naphthalene-1-sulfonyl chloride (I) with 4-nitroaniline (II) in pyridine gives the corresponding sulfonamide (III), which is reduced at the nitro group with hydrogen over Pd/C in ethanol, yielding the expected amine (IV). Finally, this compound is condensed with 3-hydroxy-2,2-dimethylpropionic acid (V) by means of propylphosphonic anhydride (PRPA) and triethylamine in dichloromethane/ethyl acetate.

参考文献No.550635
标题:A novel nonnucleosidic inhibitor of human cytomegalovirus replication
作者:Hallenberger, S.; Weber, O.; Bender, W.; Eckenberg, P.; Reefschlaeger, J.; Goldmann, S.; Trappe, J.; Haerter, M.
来源:Intersci Conf Antimicrob Agents Chemother 1999,Abst F940
合成路线图解说明:

The reaction of 5-(dimethylamino)naphthalene-1-sulfonyl chloride (I) with 4-nitroaniline (II) in pyridine gives the corresponding sulfonamide (III), which is reduced at the nitro group with hydrogen over Pd/C in ethanol, yielding the expected amine (IV). Finally, this compound is condensed with 3-hydroxy-2,2-dimethylpropionic acid (V) by means of propylphosphonic anhydride (PRPA) and triethylamine in dichloromethane/ethyl acetate.

参考文献No.561698
标题:Bay-38-4766
作者:Leeson, P.A.; Sorbera, L.A.; Casta馿r, J.
来源:Drugs Fut 1999,24(12),1297
合成路线图解说明:

The reaction of 5-(dimethylamino)naphthalene-1-sulfonyl chloride (I) with 4-nitroaniline (II) in pyridine gives the corresponding sulfonamide (III), which is reduced at the nitro group with hydrogen over Pd/C in ethanol, yielding the expected amine (IV). Finally, this compound is condensed with 3-hydroxy-2,2-dimethylpropionic acid (V) by means of propylphosphonic anhydride (PRPA) and triethylamine in dichloromethane/ethyl acetate.

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