-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	546065
标题:	Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors
作者:	Chan, L.; Jin, H.; Stefanac, T.; Lavall閑, J.F.; Falardeau, G.; Wang, W.; B閐ard, J.; May, S.; Yuen, L.
来源:	J Med Chem 1999,42(16),3023

合成路线图解说明: The condensation of 1,6-naphthyridine-2-carboxylic acid (I) with 2-isopropoxybenzylamine (II) by means of EDC and HOBT in DMF yields the target compound.

合成路线图解说明: The bromination of 1,6-naphthyridine-2-carboxylic acid (I) with Br2 in acetic acid gives the 8-bromo derivative (II), which is condensed with 2-isopropoxybenzylamine (III) by means of EDC and HOBT in DMF yielding the corresponding amide (IV). Finally, this compound is vinylated with CH2 = CH-SnBu3 and PdCl2(PPh3)2 in DMF.

合成路线图解说明: The bromination of 1,6-naphthyridine-2-carboxylic acid (I) with Br2 in acetic acid gives the 8-bromo derivative (II), which is condensed with 2-isopropoxybenzylamine (III) by means of EDC and HOBT in DMF yielding the corresponding amide (IV). Finally, this compound is methylated with Sn(CH3)4 and PdCl2(PPh3)2 in DMF.