RTI-112-药物合成数据库

【药物名称】RTI-112

化学结构式(Chemical Structure):

参考文献No.	300225
标题:	Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3beta-(3'-substituted phenyl)-, 3beta-(4'-substituted phenyl)-, and 3beta-(3', 4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters
作者:	Lewin, A.H.; Carroll, F.I.; Abraham, P.; Mascarella, S.W.; Gao, Y.; Boja, J.W.; Kuhar, M.J.; Kuzemko, M.A.
来源:	J Med Chem 1994,37(18),2865

合成路线图解说明: Conjugate addition of 4-chloro-3-methylphenylmagnesium iodide (II) to anhydroecgonine methyl ester (I) at -40 C, followed by quenching with trifluoroacetic acid at -78 C afforded a 1:1.6 mixture of 2alpha and 2beta-3-aryltropane-2-carboxylate esters (III). The target 2beta-isomer was then isolated by column chromatography.

参考文献No.	701150
标题:
作者:	Suslu, I.; Altinoz, S.
来源:	Med Chem Res 1992,1(6),382-387

合成路线图解说明: Conjugate addition of 4-chloro-3-methylphenylmagnesium iodide (II) to anhydroecgonine methyl ester (I) at -40 C, followed by quenching with trifluoroacetic acid at -78 C afforded a 1:1.6 mixture of 2alpha and 2beta-3-aryltropane-2-carboxylate esters (III). The target 2beta-isomer was then isolated by column chromatography.