【药物名称】
化学结构式(Chemical Structure):
参考文献No.548638
标题:Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy]ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors
作者:Choi, S.W.; Elmaleh, D.R.; Hanson, R.N.; Fischman, A.J.
来源:J Med Chem 1999,42(18),3647
合成路线图解说明:

The precursor bromoether (III) was prepared by condensation of 4,4?difluorobenzhydrol (I) with 2-bromoethanol (II) under acidic conditions. Treatment of 4-bromocinnamic acid (IV) with thionyl chloride afforded acid chloride (V), which was coupled with ethylenediamine (VI) to furnish mono amide (VII). The title compound was finally obtained by alkylation of amine (VII) with bromide (III) in the presence of K2CO3.

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