SoRI-9409-药物合成数据库

【药物名称】SoRI-9409

化学结构式(Chemical Structure):

参考文献No.	47884
标题:	Pyridomorphinans and use thereof
作者:	Ananthan, S. (Southern Research Institute)
来源:	WO 0112196

合成路线图解说明: The title compound was prepared by condensation of naltrexone hydrochloride (I) with 2-(4-chlorophenyl)malondialdehyde (II) in the presence of ammonium acetate in refluxing AcOH.

参考文献No.	548629
标题:	Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans
作者:	Ananthan, S.; Kezar, H.S. III; Carter, R.L.; Saini, S.K.; Rice, K.C.; Wells, J.L.; Davis, P.; Xu, H.; Dersch, C.M.; Bilsky, E.J.; Porreca, F.; Rothman, R.B.
来源:	J Med Chem 1999,42(18),3527

合成路线图解说明: The title compound was prepared by condensation of naltrexone hydrochloride (I) with 2-(4-chlorophenyl)malondialdehyde (II) in the presence of ammonium acetate in refluxing AcOH.