ODG-PFA-OMe-药物合成数据库

【药物名称】ODG-PFA-OMe

化学结构式(Chemical Structure):

参考文献No.	547758
标题:	Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery
作者:	Avila, C.P.; Gardner, M.F.; Freeman, W.R.; Keef, K..S.; Bergeron-Lynn, G.; Cheng, L.Y.; Hostetler, K.Y.; Beadle, J.R.; Wiley, C.A.
来源:	J Ocular Pharmacol Ther 1999,15(4),363

合成路线图解说明: The title compound was prepared by coupling 1-O-octadecyl-sn-glycerol (I) with methyl phosphonoformate (II) in the presence of DCC in pyridine, followed by conversion to the monosodium salt by means of an aqueous solution of NaHCO3.