【药物名称】
化学结构式(Chemical Structure):
参考文献No.560922
标题:Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists
作者:Itoh, K.; kanzaki, K.; Ikebe, T.; Kuroita, T.; Tomozane, H.; Sonda, S.; Sato, N.; Haga, K.; Kawakita, T.
来源:Eur J Med Chem 1999,34(11),977
合成路线图解说明:

4-Amino-5-chloro-2-methoxybenzoic acid (I) was coupled to 4-(aminomethyl)-1-[2-(methylsulfonylamino)ethyl]piperidine (II) employing 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride and 1-hydroxybenzotriazole. The resulting compound was then treated with oxalic acid to provide the corresponding oxalate salt.

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